自噬在阿尔茨海默病中的作用机制及治疗前景

The Mechanism and Treatment of Autophagy in Alzheimer's Disease

自噬过程受到一系列复杂信号分子的调控。基础水平的自噬在清除异常积聚的蛋白质、长寿命蛋白以及受损细胞器、维持细胞内稳态和细胞生存中扮演重要角色。阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知障碍和记忆力损害为主的脑部神经退行性疾病,其发病机制尚未明确,目前仍无有效的治疗方法。介绍自噬和阿尔茨海默症的关系和药物治疗,旨在为AD相关药物的开发及合理利用提供实验依据。

The process of autophagy is regulated by a series of complex signal molecules. Basal levels of autophagy play an important role in clearing abnormally accumulated proteins, long-lived proteins and damaged organelles, maintaining cell homeostasis, and cell survival. Alzheimer’s disease(AD) is a brain neurodegenerative disease mainly characterized by progressive cognitive impairment and memory impairment. Its pathogenesis is not yet clear, and there is still no effective treatment. This article describes the relationship between autophagy and Alzheimer’s disease and drug treatment, aims to provide an experimental basis for the rational development and utilization of AD-related drugs.