基因表达谱技术从消化道肿瘤基础研究到临床转化

Gene expression profiling in digestive tract tumors: From basic research to clinical practice

基因表达谱技术是进行全基因组功能研究的一种新技术新方法,也是生命科学与信息科学相结合的一种综合性研究技术手段.基因表达谱在消化道肿瘤研究中,就针对其基因功能、发病机制、基因网络调控及生物学特性等方面进行了深入的基础性研究,同时也已转化应用于临床病理诊断、鉴别诊断、分子分型、靶向治疗等方面的探讨.但要对这一转化过程中不断产生的海量数据进行充分的挖掘与利用,对现有基因表达数据库进行有效的规范化建设与管理,应逐步实现数据共享,加强基因表达谱技术质量控制,才能使基因表达谱技术在未来的研究中得到健康、稳定和快速的发展.

Gene expression profiling is a new method that can beused to study the whole genome function. It is also a comprehensive research technique combining life science with information science. Gene expression profiles have not only been thoroughly and fundamentally studied in digestive tract tumors with regard to gene function, pathogenesis, gene network regulation, and biological characteristics, but also been applied to clinical diagnosis, differential diagnosis, molecular typing, targeted therapy, and other aspects. However, it is still necessary to fully mine and utilize the huge amount of data generated continuously in this process, effectively standardize the construction and management of the existing gene expression database, gradually realize data sharing, and strengthen the quality control of gene expression profiling technology in order to make the gene expression profiling technology become more stable and rapid in the future research.