人脑胶质瘤中TRIM27的基因表达及临床意义

The expression of TRIM27 in human glioma and its clinical significance

目的检测TRIM27(tripartite motif 27)在人脑胶质瘤(以下简称胶质瘤)中的表达情况并分析其临床意义。方法采用逆转录—聚合酶链反应(RT-PCR)技术,检测TRIM27 mRNA在32例不同病理级别的胶质瘤组织中的表达,统计分析其表达与患者临床病理指标的相关性。结果在所检测的胶质瘤组织中,TRIM27 mRNA的阳性表达率为43. 8%(14/32); TRIM27 mRNA的表达与胶质瘤患者的年龄、性别、肿瘤大小和WHO分级等临床指标均无关(P> 0. 05)。结论 TRIM27在胶质瘤中具有一定的表达频率,但能否作为胶质瘤诊断和治疗的新靶点仍待进一步评估。

Objective To detect the expression of TRIM27 in human glioma and analyze its clinical significance. Methods The expression of TRIM27 mRNA in glioma tissues of 32 patients with different pathological grades was detected by RT-PCR. The correlation between TRIM27 expression and clinicopathological parameters was analyzed. Results The results showed that the positive expression rate of TRIM27 was 43. 8% (14/32). There was no correlation between the expression of TRIM27 and clinical indicators such as age,sex,tumor size and WHO grade (P >0. 05). Conclusion TRIM27 has a certain expression frequency in glioma,but whether TRIM27 can be used as a new target for diagnosis and treatment of glioma remains to be further evaluated.