2型糖尿病患者微量白蛋白尿与甲状腺功能的相关性研究

Association between thyroid function and microalbuminuria in patients with type 2 diabetes mellitus

目的探讨T2DM患者甲状腺功能与微量白蛋白尿(MAU)的相关性。方法选取1167例于我院内分泌科住院治疗的T2DM患者,分析甲状腺激素水平与MAU的相关性。结果本研究MAU患病率为17.7%(206/1167)(MAU组),其余961例为正常尿蛋白组(NAU)。与NAU组比较,MAU组年龄更大[(59.27±15.24)vs(55.33±12.60)岁,P<0.01],糖尿病病程更长[13.00(7.00,19.00)vs 10.00(4.00,15.00)年,P<0.01],SBP[(136.76±16.90)vs (128.62±16.43)mmHg,P<0.01]、FPG[(8.10±2.92)vs (7.64±2.71)mmol/L,P<0.05]、HbA1c[(9.27±1.80)%vs (8.97±1.97)%,P<0.05]、SUA[(347.9±98.9)vs(331.9±87.6)μmol/L,P<0.05]水平更高,游离三碘甲状腺原氨酸(FT3)水平更低[(4.41±0.53)vs(4.59±0.51)pmol/L,P<0.05]。Logistic回归分析结果显示,校正年龄、糖尿病病程、SBP、HbA1c、SUA水平后,FT3水平与MAU呈负相关。结论 FT3水平与T2DM患者微量白蛋白尿呈独立负相关。

Objective To investigate the association between thyroid function and microalbuminuria in type 2diabetes mellitus (T2DM). Methods A total of 1,176T2DM patients hospitalized in the Department of Endocrinology in our hospital were included in the study.The clinical and laboratory characteristics were documented. Results The prevalence of microalbuminuria was 17.7% (206/1167)in this study population (MAU group), the 961cases were normal albuminuria group (NAU).Compared with normal albuminuria group,there were significantly higher age [(59.27±15.24)vs (55.33±12.60)year,P<0.01 ], duration of diabetes [ 13.00 (7.00,19.00)vs 10.00 (4.00,15.00)year,P<0.01 ], systolic blood pressure [ SBP (136.76±16.90)vs (128.62±16.43)mmHg,P<0.01 ], fasting blood glucose [ FPG (8.10±2.92)vs (7.64±2.71)mmol/L,P<0.05 ], glycosylated hemoglobin [ HbA 1 c (9.27±1.80)% vs (8.97±1.97)%,P<0.05 ] in the microalbuminuria group were lower than those in the normal albuminuria group.Logistic regression analysis showed that FT 3 was negatively associated with the prevalence of microalbuminuria after adjusting for age,duration of diabetes,SBP,HbA 1 c and SUA. Conclusion There is an independent negative association between serum FT 3 and the prevalence of microalbuminuria in T2DM patients.