创伤后毛细血管渗漏综合征液体治疗策略

Fluid management strategies for post -trauma capillary leak syndrome

创伤后毛细血管渗漏综合征(trauma induced capillary leak syndrome,T -CLS)是严重创伤的重要并发症之一,一旦发生可能严重影响患者预后。目前,T-CLS尚无明确的诊断标准。液体治疗是T-CLS预防与治疗中非常重要的措施之一。T-CLS不同病程阶段对液体治疗的要求各不相同,创伤早期合理的复苏策略可降低T-CLS发生的风险;而T-CLS一旦发生,应根据临床分期、血管内皮损伤严重程度、循环状态,以及是否合并器官功能障碍等因素,制定个性化的液体治疗方案。本文旨在现有研究基础上探讨T-CLS液体治疗的策略。

Trauma -induced capillary leak syndrome (T -CLS)is one of the important complications of severe trauma,which may seriously affect the prognosis of patients.There is currently no established definition of T-CLS.Fluid management is one of the critical interventions for the prevention and treatment of T -CLS.The strategies for fluid management vary from different stages of T -CLS.A reasonable early recovery strategy for trauma patient may reduce the risk of the onset of T - CLS.Once T -CLS occurs,individualized fluid management should be provided based on the given clinical features such as stage,severity of endothelial injury,circulatory status,and whether organ dysfunction is combined.