沈阳市新生儿血管瘤发病与空气质量关系

Relationship between neonatal hemangioma incidence and air quality in Shenyang city

目的了解辽宁省沈阳市新生儿血管瘤发病与空气质量的关系,为血管瘤的预防提供参考依据。方法收集沈阳市2006年1月1日—2010年12月31日13个区(县)63个监测点上报的新生儿血管瘤发病数据和沈阳市环境监测中心环境质量报告书中报告的空气质量(SO_2、NO_2、PM10)监测数据,分析空气中SO_2、NO_2、PM10暴露浓度与新生儿血管瘤发病的关系。结果沈阳市2006—2010年SO_2、 NO_2和PM10的平均浓度分别为(0.058±0.060)、(0.038±0.019)和(0.113±0.063)mg/m3;沈阳市2006—2010年新生儿血管瘤发病率为13.86/万,2006、2007、2008、2009、2010年新生儿血管瘤发病率分别为6.13/万、18.49/万、20.79/万、13.51/万、9.21/万,不同年份新生儿血管瘤发病率差异有统计学意义(χ~2=61.59,P <0.05);新生儿血管瘤发病率与母亲妊娠初期3个月的SO_2和PM10暴露浓度变化趋势基本一致,而与NO_2暴露浓度变化趋势不一致。结论沈阳市妊娠期妇女在妊娠初期3个月SO_2和PM10暴露浓度与新生儿血管瘤发病有关。

Objective To explore the relationship between the incidence of neonatal hemangioma and ambient air quality in Shenyang city and to provide references for the prevention of hemangioma.Methods We collected data on neonatal hemangioma incidents reported by 63 disease surveillance sites in 13 districts(counties)of Shenyang municipality from January 1, 2006 to December 31, 2010, and extracted the data on ambient air concentrations of sulfur dioxide( SO2), nitrogen dioxide(NO2), and particulate matter less than 10 μm in aerodynamic diameter(PM10)form Environmental Quality Report issued by Shenyang Environmental Monitoring Center simultaneously. Then we analyzed the relationship between the concentration of SO2, NO2, and PM10 in ambient air and the incidence of neonatal hemangioma.Results During the 5-year period, the average concentrations of SO2, NO2 and PM10 in ambient air in the city were 0.058±0.060, 0.038±0.019, and 0.113±0.063 mg/m3 and the mean incidence rate of neonatal hemangioma was 13.86/10 000. The annual incidence rates of neonatal hemangioma were 6.13, 18.49, 20.79, 13.51, and 9.21 per 10 000 neonates in 2006, 2007, 2008, 2009, and 2010, respectively, with a significant yearly difference(χ2= 61.59, P<0.05). The variation in the incidence of neonatal hemangioma was basically consistent with the that of ambient air concentration of SO2 and PM10 but not consistent with that of NO2 for residential area of the pregnant women during the first 3 months of pregnancy.Conclusion Pregnant women's exposure to SO2 and PM10 in ambient air during the first trimester of pregnancy may associate with the incidence of neonatal hemangioma in Shenyang city.