中医定向透药治疗联合沙美特罗替卡松对COPD患者的治疗效果及对炎症因子、肺功能的影响

Effect of TCM Directional Penetration Therapy Combined with Salmeterol Fluticasone in Treatment of COPD and Its Influence on Inflammatory Factors and Lung Function

目的观察中医定向透药治疗联合沙美特罗替卡松对慢性阻塞性肺疾病(COPD)患者的治疗效果及对炎症因子、肺功能的影响。方法选择在我院诊断且符合纳入标准的80例COPD患者作为研究对象,采用随机数字表法将其分为观察组和对照组,每组各40例,对照组予以沙美特罗替卡松治疗,观察组在对照组基础上加用中医定向透药治疗,比较两组患者的治疗效果、血清炎症因子水平和肺功能指标水平。结果观察组的临床治疗总有效率明显高于对照组(<0.05);治疗后,两组血清肿瘤坏死因子-(TNF-)、高迁移率族蛋白B1(HMGB1)水平均明显低于治疗前(<0.05),且观察组明显低于对照组(<0.05);治疗后,两组第1秒最大呼气量(FEV1)、呼气流量峰值(PEF)、第1秒呼气容积占用力呼气量百分比(FEV1/FVC)水平均高于治疗前(<0.05),且观察组明显高于对照组(<0.05)。结论中医定向透药治疗联合沙美特罗替卡松对COPD患者具有较好的治疗效果,其可明显降低COPD患者血清炎症因子水平,改善肺功能。

Objective To analyse the effect of TCM directional Penetration therapy combined with salmeterol fluticasone on chronic obstructive pulmonary disease (COPD)patients and its influence on inflammatory factors and lung function.Methods 80 cases of patients with COPD were randomly divided into observation group and control group,40 cases in each group. Control group was treated with salmeterol fluticasone,observation group received TCM directional Penetration therapy on the basis of control group,the therapeutic effect,serum level of inflammatory factors and lung function index level of the two groups were compared.Results The total effective rate of observation group was significantly higher than that of control group (P<0.05);after treatment,the serum levels of tumor necrosis factor-alpha (TNF-α)and high mobility group protein B 1 (HMGB 1) in both groups were significantly lower than those before treatment (P<0.05),observation group was significantly lower than that of control group (P<0.05);the levels of the first second maximum expiratory volume (FEV1),peak expiratory flow (PEF), first second expiratory volume-occupancy percentage (FEV1/FVC)in both groups were higher than those before treatment (P<0.05),observation group was significantly higher than those of control group (P<0.05).Conclusion TCM directional penetration therapy combined with salmeterol fluticasone has a good therapeutic effect on patients with COPD,it can significantly reduce the level of serum inflammatory factors and improve lung function.