摘要
AIM: To evaluate the efficacy of 0.1% topical salicylic acid（TSA） to treat iatrogenic chronic blepharoconjunctivitis in patients with primary open angle glaucoma（POAG）, treated with topical prostaglandin analogues（TPAs）.METHODS: Totally 60 patients were randomly distributed into 3 equal size groups, two of which treated with 0.1% TSA（OMKASA;） and 0.1% topical clobetasone butyrate（TCB; VISUCLOBEN;） respectively, and one consisting of untreated controls. The parameters taken into account at baseline（T0） and after 30 d（T1） of therapy were: conjunctival hyperemia, lacrimal function tests [Schirmer I test and break up time（BUT）] and intraocular pressure（IOP）.RESULTS: Conjunctival hyperemia showed a substantial improvement in both treated groups（P<0.001） but not among controls. Similarly, lacrimal function tests displayed an improvement of Schirmer I test in both treated groups（P<0.05） and an extension of BUT only in the group treated with 0.1% TSA（P<0.05）. The IOP increase was statistically significant only in those patients treated with 0.1% TCB（P<0.001）.CONCLUSION: The 0.1% TSA has proved to be an effective anti-inflammatory treatment of blepharoconjunctivitis affecting glaucoma patients on therapy with TPAs, leading to a sizeable decrease of inflammation as well as both quantitative and qualitative improvement of tear film. Furthermore, differently from 0.1% TCB, it does not induce any significant IOP increase.
AIM: To evaluate the efficacy of 0.1% topical salicylic acid(TSA) to treat iatrogenic chronic blepharoconjunctivitis in patients with primary open angle glaucoma(POAG), treated with topical prostaglandin analogues(TPAs).METHODS: Totally 60 patients were randomly distributed into 3 equal size groups, two of which treated with 0.1% TSA(OMKASA~?) and 0.1% topical clobetasone butyrate(TCB; VISUCLOBEN~?) respectively, and one consisting of untreated controls. The parameters taken into account at baseline(T0) and after 30 d(T1) of therapy were: conjunctival hyperemia, lacrimal function tests [Schirmer I test and break up time(BUT)] and intraocular pressure(IOP).RESULTS: Conjunctival hyperemia showed a substantial improvement in both treated groups(P<0.001) but not among controls. Similarly, lacrimal function tests displayed an improvement of Schirmer I test in both treated groups(P<0.05) and an extension of BUT only in the group treated with 0.1% TSA(P<0.05). The IOP increase was statistically significant only in those patients treated with 0.1% TCB(P<0.001).CONCLUSION: The 0.1% TSA has proved to be an effective anti-inflammatory treatment of blepharoconjunctivitis affecting glaucoma patients on therapy with TPAs, leading to a sizeable decrease of inflammation as well as both quantitative and qualitative improvement of tear film. Furthermore, differently from 0.1% TCB, it does not induce any significant IOP increase.
