趋化因子CXCL16及其受体CXCR6与纤维化

Chemokine axis CXCL16/CXCR6 in the progression of fibrosis

纤维化(fibrosis)是多种病变的共同病理基础,主要表现为组织内胶原沉积及纤维结缔组织增多,原有的组织结构破坏及功能受损。目前有关纤维化的发病机制尚不明确,亦缺乏有效的治疗与预防手段。近年来,大量的研究表明趋化因子CXCL16及其受体CXCR6在纤维化的发生发展中扮演重要角色。本文从CXCL16/CXCR6的生物学特性及其在纤维化中的作用两个方面进行归纳总结。

Fibrosis is the common pathological basis of various lesions. It is mainly manifested as excess collagen deposition and fibrous connective tissue in tissues with destructed structures and impaired function. At present, the pathogenesis of fibrosis is still unclear, and no effective treatment or prevention for fibrosis is available. In recent years, numerous studies have shown that chemokine CXCL16 and its receptor CXCR6 play an important role in the development of fibrosis. This paper summarizes the biological characteristics of CXCL16/CXCR6 axis and its role in fibrosis.