微流控技术用于制备纳米制剂的研究进展

Advances of Microfluidic Technology in the Preparation of Nanoparticulate Drug Delivery Systems

纳米药物递送系统的研究进展迅速,多项研究表明该系统对疾病的诊断和治疗具有一定的应用潜力。但纳米药物递送系统的工业转化速度较为缓慢,主要是由常规制备方法的局限性所致,包括批次间质量差异大和工业化放大可行性差等。微流控技术对于流体的混合具有良好的可控性和重现性,能够突破常规制备方法的局限,加快纳米药物制剂的工业化和临床转化。从微流控纳米沉淀法的机制和特点、相关的微流控装置以及所制备的纳米药物制剂等3个方面,对微流控技术用于制备纳米制剂的研究进展进行综述。

Nowadays significant progress has been made in the study of nanoparticulate drug delivery systems which hold great potentials for the diagnosis and therapy of many diseases. However, the rate of industrial and clinical translation of these systems is slow, mainly due to the limitations of conventional preparation methods such as high batch-to-batch variations in physicochemical properties and poor feasibility in process scale-up. With good controllability and reproducibility in fluid mixing, microfluidic technology has been utilized to overcome the limitations of conventional precipitation methods and accelerate the industrial and clinical translation of nanoparticulate drug preparations. This article reviewed the advances of microfluidic technology in the preparation of nanoparticulate drug delivery systems from the perspectives of principles and characteristics of microfluidic precipitation, the engineering of microfluidic devices, and the prepared nanoparticulate drugs.