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糖尿病心肌病治疗药物研究进展 被引量:4

Research Progress in Therapeutic Drugs for Diabetic Cardiomyopathy
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摘要 糖尿病心肌病(DCM)是糖尿病主要并发症之一,是独立于高血压性心脏病、冠状动脉粥样硬化性心脏病、心脏瓣膜病及其他已知心脏疾病的心脏特异性病变,最终进展可致患者心力衰竭和死亡。因此,DCM的治疗药物备受关注,将从西药和中药2个方面对DCM的治疗药物研究进展进行综述,以期为临床提供参考。 Diabetic cardiomyopathy (DCM) is one of the major complications of diabetes. It is a unique set of heart-specific pathological variables in diabetic patients, independent of hypertensive heart disease, coronary atherosclerotic heart disease, valvular heart disease and other heart diseases. The final progress of DCM can lead to heart failure and death. Therefore, the treatment of DCM has attracted increased attention. The research progress in therapeutic drugs for DCM was reviewed from the aspects of western medicine and traditional Chinese medicine, so as to provide reference for clinical treatment.
作者 王慧 丁选胜 WANG Hui;DING Xuansheng(School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China)
出处 《药学进展》 CAS 2018年第11期860-867,共8页 Progress in Pharmaceutical Sciences
基金 国家自然科学基金(No.81274158)
关键词 糖尿病心肌病 治疗药物 西药 中药 diabetic cardiomyopathy therapeutic drug western medicine traditional Chinese medicine
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  • 1Vijay Sharma,John H McNeill.Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: Confronting the maze[J].World Journal of Cardiology,2011,3(9):281-302. 被引量:8
  • 2Garcia MJ, McNamara PM, Gordon T, KannelWB. Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes 1974; 23: 105-11.
  • 3Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A. New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 1972; 30: 595-602.
  • 4Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, et al. Attenuatior by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coil Cardiol 2006; 48: 1688-97.
  • 5Cai L. Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy. Free Radic Biol Med 2006; 41: 851-61.
  • 6Barouch LA, Berkowitz DE, Harrison RW, O'Donnell CP, Hare JM. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 2003; 108: 754-9.
  • 7Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci USA 2000; 97: 1784-9.
  • 8Wold LE, Ren J. Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase- dependent oxidative stress mechanism. Biochem Biophys Res Commun 2004; 318: 1066-71.
  • 9Cai L, Li W, Wang G, Guo L, Jiang Y, Kang YJ. Hyperglycemiainduced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 2002; 51: 1938-48.
  • 10Kwon SH, Pimentel DR, Remondino A, Sawyer DB, Colucci WS. H(2)O(2) regulates cardiac myocyte phenotype via concentration- dependent activation of distinct kinase pathways. J Mol Cell Cardiol 2003; 35: 615-21.

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