非选择性β受体阻滞剂在肝硬化并食管胃静脉曲张中的使用与争议

Application and the controversy of non-selective beta blocker in the treatment of gastroesophageal varices in cirrhosis

食管胃静脉曲张是肝硬化门脉高压常见并发症之一,发病率高,其破裂出血常导致肝硬化患者突然死亡。防治静脉曲张破裂出血及预防再出血十分重要。非选择性β受体阻滞剂能降低门脉压力,预防曲张静脉出血和再出血获得肯定疗效,但在部分肝硬化患者中应用存在争议,本文就非选择性β受体阻滞剂在食管胃静脉曲张中的使用和争议予以阐述。

Gastroesophageal varice is a common complication of portal hypertension in liver cirrhosis.The gastroesophageal variceal bleeding often leads to the sudden death of cirrhotic patients.The prevention and the treatment ofvariceal bleeding are very important. Non-selective β-blockers (NSBB)can reduce the portal pressure and prevent variceal rebleeding,but the application of NSBB in some cirrhotic patients is controversial.This article reviewed the the application and the controversy of NSBB in the treatment of gastroesophageal varices.