白介素-8、C反应蛋白在儿童阻塞性睡眠呼吸暂停低通气综合征中的临床意义

The clinical significance of interleukin-8 and C reactive protein in children with obstructive sleep apnea hypopnea syndrome

目的探讨白介素-8(IL-8)和C反应蛋白(CRP)在儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)中的临床意义。方法选取2017年3月～2018年3月在我院就诊的80例OSAHS患儿,根据OSAHS病情分为轻、中、重度三组。同时选取60例健康儿童作对照组。检测儿童血清中IL-8和CRP水平,分析其与OSAHS发病情况的关系。结果轻、中、重度组患儿血清IL-8水平均显著高于对照组;且随着OSAHS程度的加重,血清IL-8水平显著增高,差异均有统计学意义(P<0.05)。中、重度组患儿CRP水平显著高于轻度组及对照组,且重度组患儿血清CRP水平显著高于中度组,差异均有统计学意义(P<0.05)。结论儿童OSAHS血清IL-8及CRP水平均有显著变化,且随着病情加重而明显增高。

Objective To investigate the clinical significance of IL-8 and CRP in children with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods 80 children with OSAHS in our hospital from March 2017 to March 2018 were selected and divided into light,moderate and severe three groups according to OSAHS condition.At the same time,60 healthy children were selected as the control group.The levels of IL-8and CRP of children were detected,and the re- lationship with the occurrence of OSAHS was analyzed.Results The level of IL-8 in light,moderate,severe group was significantly higher than that of the control group,and the level of IL-8 was increased with the aggravation of OSAHS (P<0.05).The level of CRP in the moderate and severe group was significantly higher than that of light group and con- trol group,and the level of the severe group was significantly higher than that in the moderate group,the differences were statistically significant (P<0.05).Conclusion There are changes of serum IL-8 and CRP levels in children with OSAHS,and it increases significantly with the aggravation of OSAHS.