摘要
铜绿假单胞菌是临床上常见的机会致病菌和耐药菌之一,它的感染常伴随着生物被膜的产生,进而造成严重的慢性感染和持续性感染。由于铜绿假单胞菌生物被膜的产生使其产生耐药性,并能够逃避宿主免疫系统的攻击,因此传统治疗方法很难将其去除。以生物被膜为靶标开发新型抗感染药物可以降低病原菌的耐药性,有望发展成1种新的治疗方法。本文总结了铜绿假单胞菌生物被膜的形成过程、主要成分的结构、生物合成过程及其功能,并对已经报道的靶向生物被膜的新型药物进行了总结。
Pseudomonas aeruginosais one of the common clinically opportunistic pathogens and drug-resistant bacteria.P.aeruginosainfections are often accompanied with the production of biofilms,resulting in chronic and persistent infections.Due to the formation of biofilm,P.aeruginosacan evade the host immune system and show antibiotics resistance,which is difficult to remove by traditional treatment methods.Therefore,it is urgent to find new anti-infection drugs,which can target biofilm.This article reviews recent advances in the formation process,the main components,biosynthetic processes and functions of each component of P.aeruginosabiofilm,and the new compounds reported to disrupt biofilms.
作者
高珊
张哲伦
苏杭
韩峰
GAO Shan;ZHANG Zhe-lun;SU Hang;HAN Feng(Key Laboratory of Marine Drugs,Ministry of Education,Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China)
出处
《中国海洋药物》
CAS
CSCD
2018年第5期86-92,共7页
Chinese Journal of Marine Drugs
基金
国家高技术研究发展计划项目(2014AA093504)
山东省自然科学基金项目(ZR2018MD021)
国家自然科学基金--山东省联合基金项目(U1606403)资助
关键词
铜绿假单胞菌
生物被膜
耐药性
Pseudomonas aeruginosa
biofilm
drug resistance