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疾病及发育中多肽:N-乙酰氨基半乳糖转移酶ppGalNAc-T的重要性 被引量:1

The importance of polypeptide N-acetylgalactosaminyltransferases in diseases and development
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摘要 蛋白质的O-GalNAc糖基化是生物体内广泛存在的一种重要的蛋白质翻译后修饰,参与了众多生命活动过程。多肽:N-乙酰氨基半乳糖转移酶(ppGalNAc-T酶)是调控蛋白质O-GalNAc糖基化修饰的起始糖基转移酶,它催化N-乙酰氨基半乳糖(GalNAc)共价结合到蛋白质丝氨酸或苏氨酸的侧链羟基上,形成Tn糖链抗原结构。人体内ppGalNAc-T酶家族共有20个成员,各成员在不同的组织和细胞中的表达具有时空特异性,同时对其修饰的底物蛋白存在选择性。ppGalNAc-T酶的异常表达与组织器官发育,以及肿瘤、家族性钙质沉积、冠心病、阿尔兹海默症、先天性心脏病等复杂性疾病的发生发展密切相关。该文总结了近年来关于ppGalNAc-T酶在组织器官发育过程以及复杂性疾病发生发展中的研究概况,为深入理解ppGalNAc-T酶和O-糖基化的功能及其生物学意义提供参考。 Mucin-type O-glycosylation(refer O-GalNAc glycosylation) is an important post-modification of protein involved in various biological processes.It is initiated by a group of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases,which transfer the GalNAc residue to the side-chain hydroxyl group on Ser or Thr of target proteins to form the Tn antigens.ppGalNAc-Ts include 20 members in human.Each isoform of ppGalNAc-Ts displays tissue-specific expression in adult mammals with substrate specificity and unique spatial as well as temporal pattern of expression during murine development.In the past decade,increasing evidence has demonstrated that aberrant expression of ppGalNAc-Ts is tightly associated with the complex diseases such as familial tumoral calcinosis,coronary heart disease,Alzheimer’s disease,congenital heart disease and the progression of various cancers as well.Here,we summarize the research overview of the expression of different ppGalNAc-Ts in normal development and these diseases,describe the functional and molecular effects of their disregulation and discuss potential molecular mechanisms underlying these processes.
作者 崔雅璐 徐颖姣 贾文娟 杨芳 张延 CUI Ya-Lu;XU Ying-Jiao;JIA Wen-Juan;YANG Fang;ZHANG Yan(Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China)
出处 《生命科学》 CSCD 北大核心 2018年第11期1264-1274,共11页 Chinese Bulletin of Life Sciences
基金 高等学校博士学科点专项科研基金资助项目(20130073110088) 国家自然科学基金面上项目(31570796,31770850).
关键词 O-GalNAc糖基化 多肽:N-乙酰氨基半乳糖转移酶 发育 疾病 肿瘤 O-GalNAc glycosylation polypeptide ppGalNAc-Ts development diseases cancers
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