摘要
将脂溶性好的金刚烷骨架引入到苯乙烯酰胺结构中合成了目标化合物(8a-8c),通过NMR,IR和LC-MS对产物进行结构表征,通过MTS方法初步研究了目标化合物对4种癌细胞增殖活性的影响.MTS实验结果表明,所得的化合物中8c可以有效地抑制癌细胞增殖,对肝癌细胞、宫颈癌细胞和乳腺癌细胞都有很低的IC50值.合成的目标化合物有望进一步研发得到结构新颖、不良反应小的抗肿瘤药物.
The target compounds(8 a-8 c)were synthesized by the introduction of lipid-soluble adamantane skeleton into styrylamide structure,and characterized by NMR,IR and LC-MS.The effect of target compounds on the proliferation activity of cancer cells lines was preliminarily studied by MTS assay.The results of MTS showed that obtained compound 8 ccould effectively inhibit the proliferation of cancer cells,and had a low IC50 value for liver cancer cells,cervical cancer cells and breast cancer cells.The target compounds synthesized in this study are expected to be further developed to obtain anti-tumor drugs with novel structure and small adverse reactions.
作者
赵银苹
陈力
侯瑞斌
夏艳
ZHAO Yin-ping;CHEN Li;HOU Rui-bin;XIA Yan(School of Chemistry and Life Science,Changehun University of Technology,Changehun 130012,China;Advanced Institute of Materials Science,Changchun University of Technology,Changchun 130012,China)
出处
《分子科学学报》
CAS
CSCD
北大核心
2018年第6期445-451,I0001,共8页
Journal of Molecular Science
基金
国家自然科学基金资助项目(21502008)
关键词
金刚烷
脂溶性
细胞增殖
MTS法
adamantane
lipid-soluble
cell proliferation
MTS assay
