孕期血清维生素A、E水平与子痫前期的相关性研究

Study on the correlations between serum vitamin A and vitamin E levels during pregnancy and preeclampsia

目的检测孕妇血清维生素A、E水平,探讨维生素A、E水平与子痫前期发病的相关性。方法2015年6月-2017年3月在西电集团医院产科门诊产检孕妇,在孕期检测两次血样(孕早、中期或孕早、晚期),共10000人次,追踪该院住院分娩者,子痫前期50例,子痫前期(重度)48例,并随机选取同期维生素A、E正常者50例作为对照组。结果孕期维生素A的异常主要表现为缺乏,缺乏状态占0.47%,亚临床缺乏状态占6.09%,过量者仅占0.94%;维生素E水平异常以过量为主,占5.74%,维生素E缺乏仅占0.03%;子痫前期和子痫前期(重度)患者孕期血清维生素A、E水平均与正常对照组无明显差异(P>0.05)。结论孕妇血清维生素A、E水平与子痫前期的发病无明显相关性。

Objective To detect the levels of serum vitamin A and vitamin E in pregnant women,explore the correlations between serum vitamin A and vitamin E levels during pregnancy and preeclampsia. Methods A total of 10 000 pregnant women receiving blood sample detection for two times during pregnancy( the first and the second trimesters of pregnancy,the first and the third trimesters of pregnancy) in Outpatient of Obstetrics in Xidian Group Hospital from June 2015 to March 2017 were selected and followed up,50 patients with preeclampsia and 48 patients with severe preeclampsia were included. Fifty normal women with normal vitamin A and vitamin E levels were randomly selected as control group. Results The main type of abnormal vitamin A during pregnancy was vitamin A deficiency,accounting for 0. 47%,the incidence rates of subclinical vitamin A deficiency and excess vitamin A were 6. 09% and 0. 94%,respectively. The main type of abnormal vitamin E during pregnancy was excess vitamin E,accounting for 5. 74%,the incidence rate of vitamin E deficiency was only0. 03%. There was no statistically significant difference in the levels of serum vitamin A and vitamin E levels during pregnancy between preeclampsia group and normal control group( P>0. 05). Conclusion The levels of serum vitamin A and vitamin E during pregnancy is not correlated with occurrence of preeclampsia.