多房棘球蚴病的免疫逃避机制

Alveolar echinococcosis and immune evasion

多房棘球蚴病是一种人兽共患寄生虫病,呈世界性分布,严重危害着人类健康和畜牧业的发展。近年来,多房棘球蚴病免疫逃逸机制成为研究热点。本文主要从改变自身抗原、细胞毒作用、负向调节免疫、改变免疫反应类型、诱导免疫细胞凋亡、免疫抑制作用及宿主的先天免疫及遗传背景等方面综述多房棘球蚴逃避宿主免疫防御攻击机制,为抗击棘球蚴病提供新的临床免疫诊疗思路。

Alveolar echinococcosis (AE) is a zoonotic parasitic disease that has a worldwide distribution and seriously threatens human health and husbandry. In recent years, the immune escape mechanism of AE has become a research hotspot. This review is focused on the immune escape mechanisms from perspectives of self-antigen alteration, cytotoxicity, negative immune regulation, alteration of types of immune response, induction of immune cell apoptosis, immunosuppression, and innate immunity and genetic background of the host, in order to provide novel insights into echinococcosis.