原发性下肢静脉曲张血管重塑相关基因的研究进展

Research progress of genes associated with vascular remodeling in lower limb primary varicose veins

原发性下肢静脉曲张(PVVs)可表现为静脉迂曲扩张、肢体沉重及肿胀,随病情发展可发生皮肤改变和难愈性溃疡等。PVVs是一种多因素疾病,尽管最常见的原因是瓣膜功能不全和静脉高压,但确切的发病机制仍不清楚,多项研究表明可能与遗传因素相关。近年来,血管重塑作为PVVs触发因素的观点逐渐得到认可,笔者对PVVs血管重塑相关的基因研究进展进行综述。

Lower extremity primary varicose veins (PVVs) can manifest as distended and tortuous veins as well as limb heaviness and swelling, and can be associated with skin changes and refractory ulcers at an advanced stage. PVVs is a multifactorial disease, and although valvular incompetence and venous hypertension are regarded to be the most common causes, the exact pathogenesis remains unclear. Various studies have suggested a potential genetic contribution. Recently, vascular remodeling has been recognized as a trigger factor for PVVs. The authors address the research progress of genes associated with vascular remodeling in PVVs.