瓦楞子散联合美沙拉嗪治疗溃疡性结肠炎

Treatment of Ulcerative Colitis with Walengzi Powder and Mesalazine

目的:探讨瓦楞子散联合美沙拉嗪治疗溃疡性结肠炎疗效及其初步作用机制。方法:选择90例溃疡性结肠炎患者,按信封随机法分为研究组45例,对照组45例。对照组予以美沙拉嗪治疗,研究组予以瓦楞子散联合美沙拉嗪治疗。采血测定炎症指标、自然杀伤细胞(natural killer cell,NK)及氧化应激指标,对比两组临床疗效以及并发症情况。结果:研究组患者有效率为91. 11%,明显高于对照组患者的有效率73. 33%(P <0. 05);两组患者经治疗后丙二醛(malondialdehyde,MDA)、一氧化氮(nitrogen monoxide,NO)及脂质过氧化(lipid peroxidation,LPO)水平降低,超氧化物歧化酶(superoxide orgotein dismutase,SOD)水平升高,白细胞介素水平升高,肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平降低,其中CD3+、CD4+及CD4+/CD8+平均水平均有升高,CD8+水平明显降低,与对照组比较,研究组MDA、NO及LPO水平较低,SOD水平较高,白细胞介素水平较高,TNF-α水平较低,CD3+、CD4+及CD4+/CD8+水平较高,CD8+水平较低,两组比较,差异具有统计学意义(P <0. 05);研究组复发率显著低于对照组,差异具有统计学意义(P <0. 05)。结论:瓦楞子散联合美沙拉嗪治疗溃疡性结肠炎疗效显著,其机制可能与降低炎症反应、提高免疫功能、增强氧自由基清除能力有关。

Objective:To investigate the efficacy and preliminary mechanism of Wualengzi Powder and Mesalazine in treatment of ulcerative colitis.Methods:Ninety patients with ulcerative colitis were enrolled and divided into two groups according to the random method,with 45patients in study group and 45patients in control group.The control group was treated with Mesalazine,and 45 patients in the study group were.treated with Wualengzi Powder and Mesalazine.Blood samples were taken for measurement of inflammation index,natural killer cell (NK)and oxidative stress.After treatment,the clinical efficacy and complications of the study group and the control group were compared.Results:After treatment,the total effective rate after treatment was 91.11%,which was significantly higher than that (73.33%)of the control group (P <0.05).After treatment,Malondialdehyde (MDA),nitrogen monoxide (NO)and lipid peroxidation (LPO)levels decreased,superoxide dismutase Orgotein Dismutase (SOD)levels increased,interleukin levels increased.The levels of tumor necrosis factor-α (TNF-α)decreased,and the average levels of CD3^+, CD4^+and CD4^+CD8^+ increased,and the level of CD8^+ decreased significantly.Compared with that of the control group,MDA, NO and The LPO levels of the study group were lower,the SOD level was higher,the interleukin level was higher,the TNF-α level was lower,the CD3^+,CD4^+ and CD4^+/CD8^+ levels were higher,and the CD8^+ level was lower.The differences between the two groups were statistically significant (P<0.05).The recurrence rate of the study group was significantly lower than that of the control group,and the difference was statistically significant (P <0.05).Conclusion :Wualengzi Powder and Mesalazine are effective in treatment of ulcerative colitis.The mechanism may be related to reducing inflammation,improving immune function and enhancing oxygen free radical scavenging ability.