肿瘤发病机制的中医系统学诠释

Interpretation of Pathogenesis of Tumor Based on Systems Science on Chinese Medicine

在中医系统学框架内,机体有三大生理功能:气化、运化、疏泄。其中气化与运化是影响整体状态的两个序参量,疏泄则是调节两者间平衡的中介参量。气化受损可致虚,运化不及则为瘀,疏泄不力可生毒。从典型的肿瘤患者发病情况看,通常都有"累""乱""气"三种情况。累,伤及肺肾,导致气化功能降低,出现"虚";乱,损及心脾,以致运化功能障碍,出现"瘀";气,伤害心包与肝,造成疏泄功能失衡,出现"毒"。三者叠加,非线性相互作用,引起机体节奏紊乱,触及某个临界点时,肿瘤发生。肿瘤是最有代表性的慢病,发病过程、临床表现、治疗反应均个体化差异很大,临界点的不同是导致差异的关键要素。了解肿瘤发病机制,不仅可以强有力地推进肿瘤防治,也有助于全面深入认识慢病的一般规律。

In the frame of systems science on Chinese medicine,there are three physiological functions of human body,activity of qi,transformation and dispersing.Among them,activity of qi and transformation are two key parameters to influence the whole state,and dispersing is the medium parameter to balance them. Wastage of activity of qi can lead to deficient syndrome,abnormal transformation will be followed by stasis and poor dispersing is going together with poison.In typical situation of tumor,fatigue,chaos and getting angry are commonly seen.Fatigue harms lung and kidney,reduces the activity of qi and is the reason of deficient syndrome.Chaos damages heart and spleen,violates transformation and gives rise to stasis.Getting angry injures pericardium and liver,causes abnormal dispersing and produces poison.Non-linear interactions among the three agents may result in chaos of life rhythm and evoke tumor at a just critical point.Tumor is the most representative one of chronic diseases ,and its development,clinic manifestation and treating reaction all show great individual difference.Several critical points are the main cause of the difference.Studying the pathogenesis of tumor not only can push forward the prevention and cure of tumor forcefully,but also is helpful to recognize the general laws of chronic diseases comprehensively and deeply.