骨质疏松症相关细胞因子研究进展

Progress in research on cytokines associated with osteoporosis

骨质疏松症是一类多发于老年人的全身性骨病,是老年患者致残、致死的主要原因。骨质疏松症的发生、发展不仅与骨量减低、骨髓中脂肪含量增多有关,还与全身骨骼肌含量、强度等关系密切。鉴于骨骼、肌肉及脂肪组织的相关细胞因子在此过程中发挥的重要作用,本文针对近年来颇受关注的骨形态发生蛋白、转化生长因子beta、成纤维细胞生长因子等细胞因子作以下综述,以期为骨质疏松症的早期诊断、疗效观察及并发症治疗等提供新的视角。

Osteoporosis is a kind of systemic bone disease,highly prevalent in the elderly,and is the main cause of disability and death in elderly patients.The occurrence and development of osteoporosis is not only related to the decrease of b.one mass and the increase of fat content in the bone marrow,but also closely related to the volume'and strength of skeletal muscle.In view of the important role of cytokines in bone,muscle and adipose tissue in this process,we focused the following review on cytokines that receive great attention recently,including bone morphogenetic protein,transformation growth factor beta,fibroblast growth factor, etc.in order to provide a new perspective for the early diagnosis,curative effect observation and complication treatment of osteoporosis.