有惊厥史儿童的预防接种方法研究及应用

Vaccination of children with seizure histories

目的探讨有惊厥病史儿童的预防接种方法。方法收集预防接种中有惊厥病史儿童病例,聘请临床、流行病学、疫苗学等领域专家进行论证,形成有惊厥病史儿童预防接种专家建议(试行),并在北京市顺义区实施,观察接种后不良反应。结果对于热性惊厥的儿童,建议在惊厥恢复后1年内无再次出现热性惊厥,且脑电图正常,予以疫苗接种;对于非热性惊厥的儿童,在原发疾病痊愈后即可恢复接种。顺义区5家接种单位对19名有惊厥病史的儿童进行了10种疫苗的82剂次接种,未出现不良反应。结论形成的有惊厥病史儿童预防接种专家建议具有较好的可行性和有效性,对日常预防接种工作有很强的指导意义。

Objective To discuss vaccination of children with histories of seizures.Methods We collected a cohort of children that had histories of seizures and invited clinical,epidemiological,and vac- cine experts and experts in other fields to discuss and develop guidelines for vaccination for children that have a history of seizures.We used the guidelines in childhood vaccination services in the Shunyi district of Beijing and observed the children for adverse reactions after vaccination.Results Children with febrile seizures and a normal EEG were suggested to be vaccinated after 1year of being seizure-free.Children with non-febrile seizures were suggested to be vaccinated after recovering from primary diseases.In 5 vaccination clinics in Shunyi,82 doses of 10 different vaccines were administered to 19 children with seizure histories;no adverse reactions occurred.Conclusions The guideline for vaccination of children with seizures was feasible and effective;it may be an important guideline for routine vaccination.