系统性红斑狼疮患者人巨细胞病毒抗体检测的临床意义

Clinical significance of human cytomegalovirus antibody assay in patients with systemic lupus erythematosus

目的分析系统性红斑狼疮(systemiclupuserythematosus,SLE)患者HCMV抗体与其临床指标的相关性。方法利用电化学发光法检测87例SLE患者及72例对照组血清特异性抗HCMV Ig G和Ig M抗体阳性率及浓度,分析结果与SLE临床指标的相关性。结果对照组抗HCMV-Ig G抗体的阳性率为98. 61%,SLE组阳性率为100. 00%,2组之间差异无统计学意义(P> 0. 05)。对照组抗HCMV-Ig M抗体的阳性率为0. 00%,但SLE组阳性率为8. 05%,2组之间差异有统计学意义(P <0. 05)。比较2组人群的抗体浓度发现,SLE组的抗HCMV-Ig G抗体浓度明显高于对照组(P <0. 01),但抗HCMV-Ig M抗体浓度在2组之间差异无统计学意义(P> 0. 05)。进一步分析HCMV血清学与SLE临床指标的相关性,结果显示不同的HCMV抗体浓度其临床指标的差异存在不同的特征。结论 HCMV感染与SLE存在相关性,具体的机制需要进一步研究。

Objective To explore the correlation between HCMV antibody assay and clinical indicators of systemic lupus erythematosus(SLE).Methods The positive rate and concentration of serum anti-HCMV-specific IgG and IgM antibodies in 87patients with SLE and 72controls were detected by electrochemiluminescence.The correlation between the results and the clinical indicators of SLE was analyzed.Results The positive rate of anti -HCMV -lgG antibody in the control group was 98.61%,and the positive rate in the SLE group was 100.00%.There was no statistical significance on the difference between the two groups (P >0.05).The positive rate of anti -HCMV-IgM antibody in the control group was 0.00%,but the positive rate in the SLE group was 8.05%,and the difference between the two groups was statistically significant (P <0.05).The antibody concentration in the two groups was significantly higher than that in the control group (P <O.O1),but the concentration difference of anti-HCMV -IgM antibody was not statistically significant between the two groups (P >0.05).Further analysis of the correlation between HCMV serology and clinical indicators of SLE showed that different HCMV antibody concentrations have different characteristics in clinical indicators.Conclusion HCMV infection was correlated with SLE,and the mechanism is worth further study.