围绝经期妇女潮热与抑郁症发生现况及关系

Incidence of hot flashes and depression in perimenopausal women and their relationship

目的探讨围绝经期妇女潮热和抑郁的相关性。方法分析2016年2月至2018年4月在西北妇女儿童医院妇女保健科就诊、咨询的围绝经期妇女1 105例,测量受试者潮热程度,并采用抑郁自评量表(SDS)评价抑郁水平,比较潮热和抑郁的相关性。结果 44.16%(488例)的女性有潮热症状,其中48.36%(236例)有普通潮热,45.49%(222例)有一般潮热,6.15%(30例)有严重潮热,55.84%(617例)无潮热症状;潮热组和非潮热组抑郁症的发生率分别为65.98%(322例)和35.01%(216例),潮热组发生抑郁症的风险是非潮热组的2.29倍;潮热组SDS得分高于非潮热组,组间比较差异有统计学意义(t=21.623,P<0.05);潮热组和非潮热组轻度抑郁发生率为23.98%(117例)、13.94%(86例),中度抑郁发生率为22.13%(108例)、11.67%(72例),重度抑郁发生率为19.88%(97例)、9.40%(58例),潮热组轻度、中度和重度抑郁发生率均高于非潮热组(χ2值分别为24.948、21.871、24.801,均P<0.05),Spearman相关性分析比较表明潮热和抑郁存在正相关(r=0.507,P=0.026)。结论围绝经期妇女潮热与抑郁存在正相关,但确切的关系需要进一步研究。

Objective To explore the correlation between hot flashes and depression in perimenopausal women.Methods From February 2016 to April 2018,1105 perimenopausal women who visited the Department of Women's Health of Northwest Women's and Children's Hospital were analyzed.The degree of hot flashes was measured and the depression level was evaluated by self-rating depression scale (SDS),and the relationship between them was analyzed.Results Totally 44.16%(488)of the surveyed women had hot flashes,among those 48.36%(236)had common hot flashes,45.49%(222)had general hot flashes, 6.15%(30)had severe hot flashes and 55.84%(617)had no hot flashes.The incidence of depression in hot flashes group and nonhot flashes group was 65.98%(322)and 35.01%(216),respectively.The risk of depression in hot flashes group was 2.29 times as that in non-hot flashes group.The score of SDS in hot flashes group was higher than that in non-hot flashes group,and the difference was statistically significant (t=21.623,P<0.05)The incidences of mild depression,moderate depression and severe depression were 23.98%(117)and 13.94%(86),22.13%(108)and 11.67%(72),and 19.88%(97)and 9.40%(58)in hot flashes group and non-hot flashes group,respectively.The incidence of mild,moderate and severe depression in hot flashes group was higher than that in non-hot flashes group (x^2 value was 24.948,21.871 and 24.801,respectively,all P<0.05).Spearman correlation analysis showed that hot flashes and depression were positiveiy correlated (r=0.507,P=0.026).Conclusion There is a positive correlation between hot flashes and depression in perimenopausal women,but the exact relationship needs further study.