头孢菌素治疗小儿上呼吸道感染效果分析

Effect of cephalosporin on upper respiratory tract infection in children

目的探讨头孢克肟与头孢克洛对小儿急性上呼吸道感染的效果及对血常规、C-反应蛋白(CRP)的影响。方法选取2017年5月至2018年5月温州医科大学附属第一医院门诊收治的经临床确诊的小儿急性上呼吸道感染患儿200例,根据不同治疗方法分为头孢克洛组(97例)和头孢克肟组(103例),对比两组患儿治疗效果、临床症状消失时间、血常规和CRP结果、不良反应发生率。结果治疗前两组患儿的白细胞、中性细胞百分比、血清CRP水平比较均无显著性差异(均P>0.05);治疗后头孢克肟组患儿的白细胞、中性细胞百分比、血清CRP水平均明显低于头孢克洛组(t值分别为19.387、21.226、20.482,均P<0.05)。头孢克肟组的临床有效率明显高于头孢克洛组(χ2=6.784,P<0.05);两组之间不良反应发生率无显著性差异(χ2=0.418,P>0.05)。头孢克肟组的发热、咽痛、咳嗽临床症状消失时间短于头孢克洛组(t值分别为3.264、5.435、3.094,均P<0.05)。结论小儿急性上呼吸道感染的治疗过程中,头孢克肟较头孢克洛的治疗效果更加理想,值得临床上推广和使用。

Objective To investigate the effect of cefixime and cefaclor on children with acute upper respiratory tract infection and their influence on blood routine and C-reactive protein(CRP).Methods Two hundred children with acute upper respiratory tract infection diagnosed in the First Affiliated Hospital of Wenzhou Medical University from May 2017 to May 2018 were divided into cefaclor group(97 cases)and cefixime group(103 cases)according to treatment.The therapeutic effect,clinical symptom disappearance time,blood routine test,CRP results and the incidence of adverse reactions were compared between two groups.Results There was no significant difference in leucocytes,the percentage of neutral cells and the level of serum CRP between two groups before treatment(all P >0.05).The leucocytes,the percentage of neutral cells and the level of serum CRP in the cefixime group were significantly lower than those in the cefaclor group after treatment(t value was 19.387,21.226 and 20.482,respectively,all P<0.05).The clinical efficacy of cefixime group was better than the cefaclor group(χ2=6.784,P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(χ2=0.418,P >0.05).The disappearance time of clinical symptoms including fever,sore throat and cough in cefixime group was shorter than that in cefaclor group(t value was 3.264,5.435 and 3.094,respectively,all P<0.05).Conclusion Cefixime is more effective than cefaclor in the treatment of acute upper respiratory tract infection in children.It is worth popularizing and using in clinic.