BP180相关自身免疫性水疱病的研究进展

BP180-related autoimmune blistering diseases

BP180相关自身免疫性水疱病包括大疱性类天疱疮、扁平苔藓样类天疱疮、线状IgA大疱性皮病、妊娠类天疱疮和瘢痕性类天疱疮。BP180胞外区含有多个自身抗体反应的位点,目前研究显示,BP180上相关自身免疫性水疱病靶位呈现出异质性,并且同一种疾病不同临床表现也与靶位异质性有关,然而异质性机制仍有待于进一步研究和探讨。

BP180-related autoimmune blistering diseases include bullous pemphigoid,lichen planus pemphigoides,linear IgA bullous dermatosis,pemphigoid gestationis and cicatricial pemphigoid. There are multiple autoantibody-reactive sites on the extracellular region of BP180.Current studies show that there is heterogeneity in the autoimmune blistering disease-related target sites on BP180,and different clinical manifestations of the same disease are related to the heterogeneity of target sites.However,further studies and analysis are still needed for the mechanism of the heterogeneity.