泛发性发疹性组织细胞瘤1例

A Case of Generalized Eruptive Histiocytoma

患者女,53岁。躯干、四肢对称性大小不等红棕色丘疹20余天,无疼痛及瘙痒。皮损组织病理示:真皮浅中层血管周围及胶原纤维间组织细胞密集浸润,间有少量淋巴细胞浸润。免疫组织化学染色示:CD68(+)、Ki-67(阳性率<5%)、S100(-)、CD1a(-)。诊断:泛发性发疹性组织细胞瘤(GEH)。给予雷公藤口服,外用丙酸氟替卡松治疗2个月后,皮损完全消退,遗留少许色素沉着斑。

A 53-year-old female presented with reddish-brown papules on the trunk and extremities with no adverse complaint for more than 20days.Histopathology revealed dense histiocyte-like cells infiltration in perivascular area and between the collagen fibers throughout the superficial dermis,along"with a few lymphocytes infiltration.The histiocyte-like infiltrates were positive for CD68 and less than 5% expression of Ki-67,but negative for CDla and S100.According to the above findings,the patient was diagnosed as generalized eruptive histiocytoma (GEH).Treatment with oral tripterygium glucosides and topical fluticasone propionate ointment for 2 months resulted in completely remission,leaving only a little pigmentation.