大黄素治疗脓毒症性凝血功能紊乱的研究进展

Research progress on the effect of emodin for Sepsis-induced coagulation disorder

祖国医学认为中药大黄具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒等功效,而脓毒症性凝血功能紊乱是临床上常见且死亡率很高的危重并发症。本文主要总结大黄素的理化性质、药代动力学特征、毒副作用,并对大黄素调节脓毒症性凝血功能紊乱的具体机制进行综述。

Traditional Chinese medicine holds that rhubarb has the functions of alleviating accumulation stagnation,clearing dampness and heat,purging fire,cooling blood,removing blood stasis and detoxifying.Septic coagulation disorder is a common serious complication with high mortality.This article mainly summarizes the physicochemical properties,pharmacokinetic characteristics and toxic and side effects of emodin,and summarizes the specific mechanism of emodin regulating coagulation dysfunction in sepsis.