APC和APE水平与急性脑梗死发生风险的相关性

Correlation between serum APC and APE levels and risk of acute cerebral infarction

目的检测抗磷脂酰胆碱抗体(APC)、抗磷脂酰乙醇胺抗体(APE)在急性脑梗死(ACI)患者血清中的表达水平,探讨其在ACI发生中的作用。方法选取87例ACI患者(ACI组)为研究对象,另选取同期健康体检者80人作为对照组。采用酶联免疫吸附(ELISA)法检测各受试者血清APC、APE水平,并进行分析。结果与对照组比较,ACI患者血清中APC、APE水平明显升高,差异有统计学意义(P<0.05)。血清APC、APE水平与患者年龄、体质比、吸烟、饮酒、高血压、糖尿病情况等有关(P<0.05)。ACI患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血糖(BG)、纤维蛋白原(FIB)水平均显著高于对照组(P<0.05),HDL-C水平显著低于对照组(P<0.05)。血清APC、APE水平与TC、TG、LDL-C、FIB、BG水平呈正相关(P均<0.05),与HDL-C水平呈负相关(P<0.05)。COX分析结果表明,血清APC、APE水平、高血压、糖尿病是影响ACI患者发生风险的独立危险因素(HR=2.948,95%CI:1.138～7.637;HR=2.134,95%CI:1.236～3.684;HR=2.383,95%CI:1.097～5.177;HR=2.471,95%CI:1.173～5.205,P均<0.05)。结论 ACI患者血清APC、APE水平升高,与患者年龄、肥胖、吸烟、饮酒、高血压、糖尿病及血脂血糖水平有关,是影响ACI患者发生风险的独立危险因素。

Objective To detect the expression levels of antiphosphatidylcholine antibody(APC) and antiphosphatidylethanolamine antibody(APE) in the serum of patients with acute cerebral infarction( ACI) and explore its role in the occurrence of ACI. Methods 87 patients with acute cerebral infarction who were diagnosed and treated in our hospital from February 2014 to February 2017 were selected as the subjects(group AC I), and 80 healthy persons taken physical examination in the same period were selected as control group. The serum levels of APC and APE were detected by enzyme linked immunosorbent assay(ELISA), and the results were analyzed. Results Compared with the control group,the levels of APC and APE in the serum of patients with acute cerebral infarction were significantly increased, and the difference was statistically significant(P<0.05). The levels of serum APC and APE were related to age, constitution ratio,smoking, drinking, hypertension and diabetes(P<0.05). The levels of total cholesterol(TC), triglyceride( TG), low-density lipoprotein cholesterol(LDL-C), blood glucose and fibrinogen(FIB) in patients with acute cerebral infarction were significantly higher than those in the control group(P<0.05); the level of HDL-C was significantly lower than that in the control group(P<0.05). The levels of serum APC and APE were positively related to the levels of TC, TG, LDL-C, FIB and BG, and had a negative correlation with the level of HDL-C(P<0.05). COX analysis showed that the serum APC level, APE level, hypertension and diabetes are independent risk factors affecting the risk of patients with acute cerebral infarction(HR=2.948, 95%CI: 1.138-7.637; HA=2.134, 95%CI: 1.236-3.684; HR=2.383, 95% CI: 1.097-5.177; HR=2.471, 95% CI:1.173~5.205,P<0.05). Conclusion The levels of serum APC and APE in patients with acute cerebral infarction were increased, and were related to age, obesity, smoking, drinking, hypertension, diabetes, blood and glucose levels. APC and APE could be independent risk factors that affected the risk of acute cerebral infarction.