摘要
各种急、慢性创面发生率较高,给患者及医疗资源带来极大负担,干细胞疗法目前被广泛应用于临床研究,移植后能够有效修复损伤组织。但由于受到感染、缺氧、炎性因子等多种因素的影响,移植后干细胞存活率低下,无法有效归巢至损伤组织。因此,增加干细胞在体效率对促进创面修复有至关重要的作用。预处理干细胞能够改变细胞生物学活性,是提高干细胞在微环境的耐受力以及归巢能力的最佳策略。本文就预处理间充质干细胞促进创面愈合的研究进展作一综述。
The incidence of various acute and chronic wounds is high, which brings great burden to patients and medical resources. Stem cell therapy is widely used in clinical research and can effectively repair injured tissue after transplantation. The survival rate of stem cells after transplantation is low due to the influence of infection, hypoxia, inflammatory factors and other factors, so it is unable to effectively homing to the injured tissue. Therefore, increasing the efficiency of stem cells in vivo plays an important role in promoting wound repair. Pretreatment of stem cells can change the biological activity of cells, which is the best strategy to improve the tolerance and homing ability of stem cells in microenvironment. This article reviews the progress of pretreated mesenchymal stem cell in promoting wound healing.
作者
王琼
刘玲英
巴特
周彪
Wang Qiong;Liu Lingyiag;Ba Te;Zhou Biao(Inner Mongolia Medical University,Huhhot 010059,China;Department of Burns,Inner Mongolia Burn Research Institute,Third Affiliated Hospital of Inner Mongolia Medical University,Baotou 014010,China;Department of Burns and Plastic Surgery,First Affiliated Hospital of People's Liberation Army General Hospital,Beijing 100048,China)
出处
《中华损伤与修复杂志（电子版）》
CAS
2018年第6期469-472,共4页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
基金
内蒙古自治区自然科学基金项目(2015MS0815)
内蒙古医科大学科技百万工程(联合)项目计划书[(YKD2016KJBW(LH)041)]
关键词
间质干细胞
伤口愈合
预处理
归巢
Mesenchymal stem cells
Wound healing
Pretreatment
Homing
