盐酸小檗碱片联合美沙拉嗪治疗远端溃疡性结肠炎的临床研究

Clinical study on Berberine Hydrochloride Tablets combined with mesalazine in treatment of distal ulcerative colitis

目的探讨盐酸小檗碱片联合美沙拉嗪治疗远端溃疡性结肠炎的临床疗效。方法收集泰州市中西医结合医院2015年1月—2017年12月收治远端溃疡性结肠炎的患者80例,随机分为对照组和治疗组,每组各40例。对照组口服美沙拉嗪缓释颗粒剂,1.0 g/次,4次/d。治疗组在对照组治疗基础上口服盐酸小檗碱片,0.2 g/次,3次/d。两组患者均连续治疗2个月。观察两组患者临床疗效,同时比较治疗前后两组患者症状消失时间和炎症因子。结果治疗后,对照组和治疗组临床有效率分别为75.00%和92.50%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者腹痛、腹泻和脓血便的临床症状消失时间明显早于对照组患者,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者炎症指标白细胞介素-6(IL-6)、IL-8和肿瘤坏死因子-α(TNF-α)较治疗前显著降低(P<0.05),IL-10较治疗前显著升高(P<0.05),且治疗组IL-6、IL-8和IL-10水平明显好于对照组(P<0.05)。结论盐酸小檗碱片联合美沙拉嗪治疗远端溃疡性结肠炎患者效果显著,尤其在减轻炎症因子方面优势明显,具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Berberine Hydrochloride Tablets combined with mesalazine in treatment of distal ulcerative colitis. Methods Patients(80 cases) with distal ulcerative colitis in TCW Integrated Hospital of Taizhou from January 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Mesalazine SR Granules, 1.0 g/time, four times daily. Patients in the treatment group were po administered with Berberine Hydrochloride Tablets on the basis of the control group, 0.2 g/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms and the inflammatory factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 75.00% and 92.50% respectively, and there were differences between two groups(P < 0.05). After treatment, the disappearance time of abdominal pain, diarrhea and pus and blood stool in the treatment group were significantly earlier than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the IL-6, IL-8, and TNF-a levels in two groups were significantly decreased(P < 0.05), but IL-10 levels were significantly increased(P < 0.05), and the IL-6, IL-8 and IL-10 levels in the treatment group were significantly better than those in the control group(P < 0.05). ConclusionBerberine Hydrochloride Tablets combined with mesalazine in treatment of distal ulcerative colitis has significant clinical efficacy, especially in alleviating inflammatory factors, which has a certain clinical application value.