微生态疗法治疗小儿抗生素相关性腹泻效果观察

Effect of Probiotics Therapy on Antibiotic Associated Diarrhea in Children

目的观察微生态疗法辅助治疗小儿抗生素相关性腹泻(AAD)的临床效果。方法收集辽阳石化总医院2017-2018年收治的AAD患儿91例,随机分为对照组46例和观察组45例。两组均接受常规对症治疗,针对腹泻对照组口服蒙脱石散,观察组在对照组基础上加用双歧杆菌四联活菌片,比较两组治疗10d后的症状评分和粪便菌落计数。结果治疗10d后,两组排便次数、性状评分及总分差异均有统计学意义(P<0.01);两组粪便各菌落计数差异也均有统计学意义(P<0.01)。结论双歧杆菌四联活菌片能有效缓解小儿AAD的症状及调理肠道菌群,值得在临床推广应用。

Objective To observe the clinical effect of probiotics therapy in adjuvant treatment of antibiotic associated diarrhea(AAD)in children.Methods A total of 91 children with AAD from 2017 to 2018 were randomly divided into control group(46 cases)and observation group(45 cases).Both groups were given routine symptomatic treatment.The control group was given montmorillonite powder orally.The observation group was given bifidobacterium tetravaccine tablets on the basis of montmorillonite powder.The symptom scores and fecal colony counts were compared between the two groups after 10 days treatment.Results After 10 days treatment,there were significant differences in defecation frequencies,stool characteristics and total scores between the two groups(P<0.01), and there were also significant differences in fecal colony counts between the two groups(P<0.01).Conclusion The bifidobacterium tetravaccine tablets can effectively alleviate the symptoms of AAD in children and regulate intestinal flora,which is worthy of clinical application.