摘要
Parkinson's disease(PD)is featured with motor disorder and nonmotor manifestations(Li et al.,2017;Zhang et al.2016) under the pathological change of Substantia Nigra(Dong et al.,2017)and non substantia nigra including medial prefrontal cortex(Li et al.,2017).Its primary motor symptoms include tremor(oscillatory movement),bradykinesia(slowness of motion),rigidity(increment of muscle tone),and postural instability,which seriously affect patients'quality of life(Du and Chen,2017).
基金
supported by the Joint Funds for the innovation of Science and Technology, Fuian province (2017Y9010)
the National Natural Science Foundation of China (81671265)
