摘要
成年哺乳动物中枢神经损伤后轴突再生能力下降以及成熟轴突细胞外环境的抑制作用共同导致轴突再生障碍。目前促进神经元轴突修复再生主要通过减少髓鞘磷脂抑制因子生成、减轻胶质瘢痕反应联合干细胞移植和神经营养因子、康复训练等途径进行。(国际眼科纵览,2018,42:361-366)
Decreased axonal regeneration after central nervous system injury in adult mammals and inhibition of the mature axon by extracellular environment together lead to axonal regeneration disorders. At present, the promotion of neuronal axon repair and regeneration is mainly carried out by reducing the production of myelin inhibitory factor, reducing the glial scar reaction combined with stem cell transplantation, neurotrophic factors, and rehabilitation training. (Int Rev Ophthalmol, 2018,42:361-366)
作者
吴娅莉
余敏斌
WU Ya-li;YU Min-bin(State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China)
出处
《国际眼科纵览》
2018年第6期361-366,共6页
International Review of Ophthalmology
基金
广东省自然科学基金(2015A030312016).
关键词
中枢神经系统
轴突再生
微环境
生长能力
信号通路
central nervous system
axon regeneration
microenvironment
growth ability
signaling pathways
