子宫内膜癌患者与人乳头状瘤病毒感染的相关性分析

Correlation Analysis between Endometrial Carcinoma and Human Papillomavirus Infection

目的探究子宫内膜癌与人乳头状瘤病毒(HPV)感染的相关性。方法在2016年1月-2017年12月在我院妇产科接受子宫病变筛查的女性中选出5000例,均进行HPV感染的检测,观察HPV感染与子宫内膜癌、子宫肌瘤等子宫病变的相关性。结果子宫肌瘤、子宫内膜癌、子宫内膜增生患者的HPV阳性率差异不显著,且各类子宫内膜病变患者的各种分型的HPV阳性率差异不显著,P>0.05;在HPV基因分型上:三种疾病之间差异不明显,均为HPV16/18概率最高,其次为HPV52和HPV58。结论人乳头状瘤病毒感染与子宫内膜癌的发病之间存在一定相关性,其中HPV16/18感染最易导致子宫内膜癌,HPV52和HPV58感染与子宫内膜癌的发病也呈显著相关性,临床上应重视HPV感染的预防。

Objective To explore the correlation between endometrial carcinoma and human papillomavirus (HPV)infection.Methods From January 2016 to December 2017,5000women who were screened for uterine lesions in the department of gynaecology and obstetrics of our hospital were selected as samples,all of whom were tested for HPV infection to observe the correlation between HPV infection and endometrial cancer,uterine fibroids and other uterine lesions.Results There was no significant difference in HPV positive rates among patients with uterine leiomyoma,endometrial cancer and endometrial hyperplasia,and there was no significant difference in HPV positive rates among various types of endometrial lesions (P >0.05).In terms of HPV genotyping, there was no significant difference among the three diseases,with the highest probability of HPV16/18,followed by HPV52 and HPV58 respectively.Conclusion There is a certain correlation between human papillomavirus infection and the incidence of endometrial carcinomaAmong which HPV16/18infection is the most likely cause of endometrial cancer,and HPV52 and HPV58 infection are also significantly related to the incidence of endometrial cancer.The prevention of HPV infection should be emphasized clinically.