基于纳米载体的多柔比星耐药干预及提高抗肿瘤效果的研究进展

Research Progress on Strategies of Overcoming Doxorubicin Resistance Based on Nanocarriers

肿瘤多药耐药(MDR)是指肿瘤细胞长期接触某一化疗药物,对多种化疗药物产生交叉耐药性。这是肿瘤细胞免受化疗药物攻击最重要的防御机制,也是导致化疗失败的主要原因。纳米载体作为一种潜在的药物递送工具,可以通过增加药物靶向性分布、实现药物选择性释放、提高细胞内摄、光化学结合以及协同递送多种活性分子等方式来实现对MDR模型的干预。笔者就纳米载体在对抗MDR方面的应用研究进行综述。

Multidrug resistance( MDR) refers to the cross-resistance of tumor cells to multiple chemotherapeutic drugs,which stems from long-term exposure to a certain chemotherapeutic drug. MDR is the most important defense mechanism for tumor cells and the main reason to failure of tumor chemotherapy. As a promising drug delivery system,nanocarriers can effectively overcome MDR by enhancing drug targeting to tumors,releasing drug selectively,increasing cellular uptake,the introduction of photochemical,and deliveing multiple active molecules synergistically. In this review,the progress on applications of nanocarriers in overcoming MDR are summarized.