摘要
设计了一例α,β-不饱和烯醛与含有双亲核活性中心的α-酮酰胺不对称有机催化高选择性的Michael-hemiaminalization-hemiacetalization串联反应,并以高收率(up to 97%)、优异的对映选择性和非对映选择性(up to>99%ee,>20∶1 dr)获得一系列具有两个顺式手性中心的二环己内酰胺化合物.
A novel enantioselective organocatalytic cascade Michael-hemiaminalization-hemiacetalization reaction of α,β-unsaturated aldehydes with α-ketoamides as binucleophiles has been developed. A series of chiral functionalized bicyclic lactams with two cis contiguous stereogenic centers have been synthesized in up to 97% yield with up to >20∶1 dr and up to >99% ee.
作者
张雄
封凯祥
夏爱宝
Zhang Xiong;Feng Kaixiang;Xia Aibao(Production Technology,Catalytic Hydrogenation Research Center;hejiang Key Laboratory of Green Pesticides and Cleaner Production Technology,Catalytic Hydrogenation Research Center,Zhejiang University of Technology,Hangzhou 310014)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2018年第12期3373-3380,共8页
Chinese Journal of Organic Chemistry
基金
浙江省自然科学基金(No.LY18B020017)资助项目~~
