摘要
报道了一种以茚酮、丙二腈、全氟烷基炔膦酸二乙酯为原料合成全氟烷基取代的芴基炔膦酸二乙酯类化合物的新方法.采用一锅合成法,可将不同基团取代的茚酮直接转化为一系列相应的全氟烷基取代的芴基炔膦酸二乙酯衍生物.整个反应过程无需金属催化,具备反应条件温和、区域选择性好、产率较高、操作简便等优点.
A simple and versatile metal-free protocol for the synthesis of perfluoroalkyated fluorene derivatives bearing phosphonate group is achieved. The reactions proceeded via one-pot three-component condensation of indenones, fluorinated alkynylphosphonates and malononitrile under mild conditions. This protocol is highly regioselective, operationally facile and applicable to a variety of indenones in good to excellent yields.
作者
孙小莉
孙振华
韩敏敏
韩靖
何伟民
陈杰
邓红梅
邵敏
张慧
曹卫国
Sun Xiaoli;Sun Zhenhua;Han Minmin;Han Jing;He Weimin;Chen Jie;Deng Hongmei;Shao Min;Zhang Hui;Cao Weiguo(Department of Chemistry, Shanghai University, Shanghai 200444;Qianweichang College, Shanghai University, Shanghai 200444;Laboratory for Microstructures, Instrumental Analysis and Research Center of Shanghai University, Shanghai 200444;State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第1期192-199,共8页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21672138)资助项目~~
