石山巴豆枝叶中1个新的降克罗烷二萜

A new norclerodan diterpene from twigs and leaves of Croton euryphyllus

目的研究石山巴豆Crotoneuryphyllus枝叶中的二萜成分。方法综合运用硅胶、MCI、高效液相等色谱技术进行化合物的分离纯化,根据化合物的波谱数据分析与文献比对进行结构鉴定。结果从石山巴豆枝叶95%提取物的石油醚部位中分离得到4个化合物,分别鉴定为crotoeurin D(1)、mallotucin C(2)、mallotucin D(3)、plaunotol(4)。结论化合物1为新的降克罗烷二萜,命名为石山巴豆素D;化合物2～4均为首次从该植物中分离得到。

Objective To study the diterpenoids from the twigs and leaves of Croton euryphyllus. Methods Compounds were isolated and purified by column chromatography on silica gel, MCI, and semi-preparative HPLC, and their structures were elucidated by spectroscopic analysis and comparisons with published literature values. Results Four compounds were obtained from the petroleum ether fraction of 95% alcoholic extract of the twigs and leaves of C. euryphyllus, and structures were identified as crotoeurin D(1), mallotucin C(2), mallotucin D(3), and plaunotol(4), respectively. Conclusion Compound 1 is a new norclerodan diterpene. Compounds 2-4 are isolated from this plant for the first time.