关于阿尔茨海默症的突触可塑性改变和中药治疗研究进展

Research Advance in Alteration of Synaptic Plasticity in Alzheimer’s Disease and Traditional Chinese Medicine Treatment

阿尔茨海默症(Alzheimer’s disease, AD)与突触的功能改变密切相关,尤其是作为疾病早期的病理改变,而且对研究记忆的形成与神经退行性改变的机制相当重要。探究影响突触功能与可塑性的病理因素,对患者恢复认知功能有重要作用,同时也可指明药物研发方向,为药物开发提供新的靶点。中药具有不良反应小、多靶点、多环节的优点,我国中药资源丰富,从中药成分中开发新的改善突触功能的抗AD药物有着重要的意义。对阿尔茨海默症中影响突触可塑性改变的病理因素及可改善突触功能的抗AD中药研究进行综述。

Alzheimer's disease is closely related with synaptic function alteration, particularly as an early pathological alteration in the disease.It also plays a significant role in investigations of memory formation and the mechanism of neurodegeneration.Searching for pathological factors that affect synaptic function and plasticity, will have significant meaning for restoring cognitive function to find out new target and guide the direction of drug development.Traditional Chinesemedicine has small toxic side effect, with multi-target, multi-channeland multi-link effect of functions and characteristics.Ingredients from Chinese medicine were extractedand developedto exploit a new drug to improve synaptic activity.This article summarizes and reviews pathological factor of synaptic plasticity deficits, and the Chinese medicine research with synaptic protective effect.