针刺对干眼症血清中炎症因子影响的随机对照试验

Randomized Controlled Trial of Effect of Acupuncture on Inflammatory Factors in Patients with Xerophthalmia

目的:探究针刺对干眼症患者血清中炎症因子影响。方法:选取2017年3月1号—2017年9月30号医院眼科门诊就诊的120例干眼症患者为研究对象,按照随机数表法将患者分为对照组和观察组,其中观察组患者行针刺治疗,每周3次,3周为1个治疗周期。对照组患者用泪然滴眼液滴眼,每日3～4次,3周为1个治疗周期。比较两组患者血清中TGF-β、TNF-α和IL-1的浓度及泪液分泌的影响及效应持续时间。结论:观察组患者治疗后TGF-β水平为(8.04±0.61)μg/L,对照组患者为(9.55±0.43)μg/L;观察组患者治疗后TNF-α水平为(9.63±4.25)μg/L,对照组患者为(12.26±6.23)μg/L;观察组患者治疗后IL-1水平为(0.13±0.03)pg/mL,对照组患者为(0.16±0.02)pg/mL,差异具有统计学意义(P<0.05);观察组患者治疗后SIT值为(6.12±1.67)mm,对照组患者为(4.98±1.82)mm;观察组患者治疗后BUT值为(5.87±1.86)s,对照组患者为(4.83±1.86)s,观察组患者治疗后乳铁蛋白水平为(1.72±0.33)g/L,对照组患者乳铁蛋白水平为(1.52±0.30)g/L,差异具有统计学意义(P<0.05);观察组患者治疗总有效率为78.3%,对照组患者治疗总有效率为65.0%,差异具有统计学意义(P<0.05)。结果:针刺能够促进干眼症患者泪液主动分泌,且针刺作为治疗手段操作简便,安全有效,值得临床推广使用。

Objective: To investigate the effect of acupuncture on serum inflammatory factors in patients with dry eye.Methods: One hundred and twenty cases of dry eye patients treated in Ophthalmology Clinic of our hospital from March 1, 2017 to September 30, 2017 were selected as the research objects.According to the random number table method, the patients were divided into control group and observation group.The observation group used acupuncture treatment, 3 times a week, 3 weeks for a treatment cycle.Patients in the control group were treated with drops of eye drops, 3 to 4 times a day, and 3 weeks as a treatment cycle.The serum levels of TGF-β, TNF-α and IL-1 in serum and the secretion of lacrimal fluid and the duration of effect were compared between the two groups.Results:The level of TGF-β in the observation group was(8.04±0.61)μg/L after treatment and(9.55±0.43)μg/L in the control group.The level of TNF-α in the observation group was(9.63±4.25)μg/L and(12.26±6.23)μg/L in the control group.IL-1 level in the observation group was(0.13±0.03)pg/mL after treatment and(0.16±0.02)pg/mL in the control group(P<0.05).The SIT in the observation group was(6.12±1.67)mmafter treatment and(4.98±1.82)mm in the control group, and BUT was(5.87±1.86)s in the observation group and(4.83±1.86)s in the control group.The lactoferrin level in the observation group was(1.72±0.33)g/L after treatment and that in the control group was(1.52±0.30)g/L, and the difference was statistically significant(P<0.05).The total effective rate of observation group was 78.3%, while that of control group was 65.0%,and the difference was statisticallysignificant(P<0.05).Conclusions:Acupuncture can promote the active secretion of tears in patients with dry eyeand acupuncture as a simple, safe and effective method of treatment is worthy of clinical promotion.