基于唾液SIgA免疫防御探讨开雍刺血法治疗喉源性咳嗽疗效机制

Clinical Observation of Kaiyong Pricking Blood Therapy in Treating Pharyngal Cough based on Salivary SIgA Immune Defense Function

目的:基于唾液SIgA免疫防御功能观察开雍刺血法治疗喉源性咳嗽的临床疗效,探讨其免疫机制。为开雍刺血法治疗喉源性咳嗽提供依据。方法:采用随机数字表法分组,将符合条件的70例患者分为开雍刺血法组(治疗组)和苏黄止咳胶囊组(对照组),各35例。治疗组给予开雍刺血法治疗,7d行1次治疗,2~3次为1个疗程。对照组给予苏黄止咳胶囊治疗,每日3次,每次3粒口服,疗程为21d。观察并记录治疗前后临床症状和体征情况以及唾液SIgA的变化情况,并记录不良反应。结果:经统计学分析,治疗组和对照组治疗喉源性咳嗽均有效,且两组治疗后唾液SIgA高于治疗前,差异有统计学意义(P<0.05),治疗组治疗前后唾液SIgA差值以及总有效率均优于对照组,差异有统计学意义(P<0.05);治疗组治疗后症状体征总分以及各因子评分均低于治疗前,且明显优于对照组,差异有统计学意义(P<0.05)。结论:开雍刺血法能快速显著缓解或消除喉源性咳嗽的症状,同时可以通过提高唾液SIgA的水平,提升患者免疫力,该方法治疗喉源性咳嗽安全有效。

Objective:To observe the clinical observation of Kaiyong pricking blood therapy in treating pharyngal cough based on salivary SIgA immune defense function,and to explore its immune mechanism. To provide the basis for the treatment of pharyngal cough by using the method of applying the blood of pricking blood therapy. Methods:Seventy patients who met the conditions were divided into two groups,Kaiyong pricking blood group(treatment group)and Suhuang Zhike Capsule group,35 cases in each group. The treatment group was given clinical observation of Kaiyong pricking blood therapy,7 days for 1 treatment,2 or 3 times for a course of treatment. The control group was given Suhuang Zhike Capsule treatment,3 times a day,3 capsules each time,the course of treatment was 21 days. Observed and recorded the clinical symptoms and signs before and after treatment,as well as saliva SIgA,and record adverse reactions. Results:The treatment group and control group were effective in treating laryngeal cough,and the difference between the two groups was statistically significant(P<0.05). The difference of salivary SIgA before and after treatment was better than that of control group,and the difference was statistically significant(P<0.05). The total score of symptoms and signs and the score of each factor were lower in the treatment group than before the treatment group,and the difference was statistically significant(P<0.05). Conclusion:Kaiyong pricking blood therapy can quickly significantly alleviate or eliminate symptoms of pharyngal cough,throat origin in alleviating symptoms at the same time can improve the level of saliva SIgA,improve the patients' immunity,the method in treatment of laryngeal source cough is safe and effective.