血清炎性因子水平与慢性阻塞性肺疾病(COPD)患者肺功能相关性研究

Correlation Study between Serums Inflammatory Factor Levels and Lung Function in Patients with Chronic Obstructive Pulmonary Disease

研究血清炎性因子水平与慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)患者肺功能的相关性,为COPD预防和控制提供指导思路。对该院2017年1月～2018年1月收治的82例慢性阻塞性肺疾病(COPD)患者按病情严重程度分为急性加重期慢性阻塞性肺疾病(AECOPD)组(40例),COPD稳定期组(42例),再选择40例体检健康者设为对照组。比较3组的血清炎性因子、肺功能、CAT问卷评分及各项指标与肺功能的相关性分析。COPD稳定期组CRP、IL-2、IL-6、IL-10、TNF-α显著高于对照组,显著低于AECOPD组(P <0. 05)。对照组无气流限制,COPD稳定期组肺功能明显高于AECOPD组(P <0. 05)。COPD稳定期组CAT总分显著高于对照组,显著低于AECOPD组(P <0. 05)。CRP、IL-2、IL-6、IL-10、TNF-α与肺功能呈正相关(P <0. 05),CAT评分与肺功能呈负相关(P> 0. 05)。血清炎性因子与慢性阻塞性肺疾病患者的肺功能呈正相关,临床可综合检查结果对患者病情严重程度及预后进行判断,并采取相应的治疗手段,从而降低疾病对患者日常生活的影响,改善其肺功能,提高临床疗效。

To study the correlation between serums inflammatory factor levels and lung function in patients with chronic obstructive pulmonary disease( COPD) and to provide guidance for prevention and control of COPD,eighty-two patients with COPD treated in Handan hospital from January 2017 to January 2018 were divided into acute exacerbation of chronic obstructive pulmonary diseases( AECOPD) group with 40 cases and COPD during stable period group with 42 cases according to the degree of disease. 40 healthy subjects were selected as the control group. The serum inflammatory factors,lung function,CAT questionnaire scores and the correlation between each index and lung function were compared among the three groups. CRP,IL-2,IL-6,IL-10 and TNF-α in the stable phase of COPD were signi-ficantly higher than those in the control group,which was significantly lower than that in the AECOPD group( P < 0. 05). There was no airflow limitation in the control group,and the lung function in the stable phase of COPD was significantly higher than that in the AECOPD group( P < 0. 05). The total score of CAT in the stable phase of COPD was significantly higher than that in the control group,which was significantly lower than that in the AECOPD group( P < 0. 05). CRP,IL-2,IL-6,IL-10 and TNF-α were positively correlated with lung function( P < 0. 05),and CAT score was negatively correlated with lung function( P > 0. 05). Serum inflammatory factors were positively correlated with lung function in patients with chronic obstructive pulmonary disease. To synthesize examination results in clinic can judge the severity and prognosis of patients,taking corresponding treatments to reduce the impact of disease on patients’ daily life and to improve lung function and clinical efficacy.