前列腺增生患者勃起功能的相关研究

Correlation Study on Erectile Function in Patients with Benign Prostatic Hyperplasia

目的探讨良性前列腺增生(BPH)患者勃起功能情况及相关因素。方法选择152例BPH患者,采用勃起功能国际问卷表(IIEF-5)将BPH患者分为勃起功能正常、轻度、中度和重度障碍4组。采用国际前列腺症状评分表(IPSS)对受试者进行BPH程度调查。分别取阴茎海绵体内血液,采用硝酸还原酶法和分光光度比色法测定血浆中一氧化氮(NO)含量及一氧化氮合酶(NOS)活性。结果 134例有勃起功能障碍(ED)(88. 16%),年龄与性功能关系密切。与正常组比较,轻、中和重度ED组中IPSS逐渐增高,NO含量及NOS活性明显减少(P <0.05)。结论年龄是导致勃起功能障碍的主要原因,BPH患者ED发生率较高,并且ED严重程度与IPSS评分之间呈正相关。阴茎海绵体内血浆中NOS活性降低、NO含量下降可能是BPH导致ED的原因之一。

Objective To investigate the erectile function in patients with benign prostatic hyperpiasia(BPH) and its related factors. Methods Totally 152 BPH patients were selected and divided into four groups of normal erectile function, mild, moderate and severe disorder by using investigate international erectile function questionnaire-5(IIEF-5). The patients were investigated about their degrees of BPH, using international prostate symptom score(IPSS). The content of nitric oxide(NO) in blood of penile corpus cavernosum was detected by nitrate reductase assay and the activity of nitric oxide synthase(NOS) was detected by colorimetric. Results 134 patients suffered from erectile dysfunction( ED)(88. 16%). Sexual function was closely related to their age. Compared with normal group, IPSS in mild, moderate and severe ED groups increased gradually. The NO content and the NOS activity were decreased significantly(P <0.05). Conclusion Age is a major cause of erectile dysfunction. The incidence rate of ED in patients with BPH is high, and the severity of ED is positively correlated with IPSS. Decrease in NOS activity and NO content in plasma of the penis may be associated with BPH-induced ED.