2型糖尿病患者校正QT间期与非酒精性脂肪性肝病的相关性分析

Correlation between QT correction interval and non-alcoholic fatty liver disease in type 2 diabetes patients

目的明确2型糖尿病患者校正QT间期(QT correction interval,QTc)与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是否存在一定的相关性。方法选取2017年7月-2018年6月在本院消化内科及内分泌科住院的549例2型糖尿病患者相关资料进行回顾性分析。QTc间期> 440 ms为QTc+组,QTc间期≤440 ms为QTc-组。对可能影响QTc间期的因素进行Logistic回归分析。结果男性(OR=0.028,95%CI 0.116～0.448,P=0.000)和红细胞计数升高(OR=0.231,95%CI 0.081～0.662,P=0.006)是糖尿病患者QTc间期延长的独立保护因素;心率增快(OR=1.040,95%CI 1.022～1.058,P=0.000)、肥胖(OR=3.350,95%CI 1.885～5.951,P=0.000)以及NAFLD(OR=1.999,95%CI 1.192～3.352,P=0.009)是糖尿病患者QTc间期延长的独立危险因素。结论 2型糖尿病患者QTc间期延长与超声检查确诊的NAFLD密切相关。

Objective To determine whether there is a certain correlation between QT correction interval(QTc)and non alcoholic fatty liver disease in patients with type 2 diabetes.Methods Clinical data about 549 patients with type 2 diabetes in the department of gastroenterology and endocrinology in our hospital from July 2017 to June 2018 were selected for retrospective analysis.QTc interval > 440 ms was defined as QTc+.QTc interval ≤ 440 ms was defined as QTc-.Factors that might affect QTc interval,such as gender,heart rate,red blood cells,hemoglobin,etc.,were analyzed by logistic regression analysis.Results Male(OR=0.028,95%CI,0.116-0.448,P<0.001)and elevated red blood cell(OR=0.231,95%CI,0.081-0.662,P=0.006)were independent protective factors of QTc interval prolongation in patients with diabetes.Elevated heart rate(OR=1.040,95%CI,1.022-1.058,P<0.001),obesity(OR=3.350,95%CI,1.885-5.951,P<0.001)and NAFLD(OR=1.999,95%CI,1.192-3.352,P=0.009)were independent risk factors for the prolongation of QTc interval in patients with diabetes.Conclusion The prolongation of QTc interval in type 2 diabetic patients is closely related to NAFLD confirmed by ultrasonography.