内蒙古锡林郭勒地区黄花蒿、大籽蒿和艾蒿花粉变应原致敏性及其临床意义

Allergenicities of Artemisia annual L, Artemisia sieversiana Willd and Aretemisia Argyi Levl.et Vant pollen in Xilin Gol district of Inner Mongolia and their clinical significances

目的探讨内蒙古锡林郭勒地区黄花蒿、大籽蒿和艾蒿3种蒿属花粉变应原的致敏性及其临床意义。方法选取2016年7-8月就诊于内蒙古锡林郭勒多伦县人民医院变态反应科的282例疑似夏秋季花粉症患者,男150例,女132例,年龄6～60(32.6±14.4)岁,进行大籽蒿花粉变应原点刺液、黄花蒿花粉变应原点刺液皮肤点刺试验;对以上两种蒿属变应原皮试均阳性患者再进行血清艾蒿sIgE水平检测。根据皮肤点刺试验强度/sIgE分级的分布情况评价不同蒿属花粉的致敏性。结果 282例疑似蒿属过敏的花粉症患者中,259例(91.8%)对黄花蒿和大籽蒿花粉变应原点刺试验均阳性。黄花蒿、大籽蒿点刺强度≥++百分比分别为100%、96.9%,艾蒿sIgE≥Ⅱ级为87.6%。结论内蒙古锡林郭勒地区3种蒿属花粉变应原均具有较强致敏性,黄花蒿致敏性强于大籽蒿。在临床确诊过程中可以单独使用黄花蒿、大籽蒿的皮肤试验或艾蒿sIgE检测诊断蒿属花粉症。

Objective To investigate the allergenicities of Artemisia annual L,Artemisia sieversiana Willd and Aretemisia Argyi Levl.et Vant pollen in Xilin Gol district of Inner Mongolia and their clinical significances.Methods A total of 282 suspected summer-autumnal pollinosis patients(150 males and 132 females with average age of 32.6±14.4 years,ranging from 6 to 60 years)admitted to Duolun People's Hospital from July to August in 2016 were enrolled in our study.All patients underwent skin prick test(SPT)using Artemisia annual L and Artemisia sieversiana Willd pollen extracts.Then Artemisia Argyi Levl.et Vant sIgE detection was performed in the patients with positive skin testing to former two Artemisia pollen allergens simultaneously.The allergenicities of these three Artemisia pollens were evaluated by analyzing the intensity of SPT or levels of sIgE.Results Of the 282 patients who might be sensitive to Artemisia by inquiry,259 patients(91.8%)were positive to Artemisia annual L and Artemisia sieversiana Willd.The cases with SPT intensity≥++ accounted for 100% in Artemisia annual L,significantly higher than 96.9% in Artemisia sieversiana Willd(P<0.001).The percentage of sIgE levels≥Ⅱ in Aretemisia Argyi Levl.et Vant was 87.6%.Conclusion In Xilin Gol district of Inner Mongolia,the allergenicities of these three Artemisia pollens are all strong.The allergenicity of Artemisia annual L is stronger than that of Artemisia sieversiana Willd.The intensity of SPT or levels of sIgE can be used alone in the diagnosis of Artemisia pollinosis.