T淋巴细胞代谢重塑与动脉粥样硬化发病

T lymphocyte metabolic remodeling and atherosclerosis

物质能量稳态是维持细胞生存和正常功能的重要条件,代谢失衡导致多种疾病的发生。近年来,细胞代谢与功能之间的关系成为对各种代谢性疾病、肿瘤及自身免疫性疾病研究的热点。本文将关注T淋巴细胞能量代谢与其激活和细胞生物学功能之间的关系及相应调节机制,并初步探讨T淋巴细胞代谢相关酶M2型丙酮酸激酶可能作为动脉粥样硬化干预靶点的新策略和意义。

Material and energy homeostasis is essential for maintaining cell survival and regular functions,and the loss of material and energy homeostasis may result in a variety of diseases.Recently,the relationship between cellular metabolism and function has become a hotspot in the study of various metabolic diseases,cancer and autoimmune diseases.This review focuses on the roles and regulatory mechanisms of T lymphocytes energy metabolism in its activation,differentiation and physiological function.It also discusses the significance of type M2 pyruvate kinase,which is the key enzyme in glycolysis,for the treatment of atherosclerosis.