D-二聚体、降钙素原、维生素D与冠心病的相关性

The correlation between D-dimer,procalcitonin,vitamin D and coronary artery disease

目的探讨D-二聚体(D-D)、降钙素原(PCT)、维生素D(Vit D)与冠心病的相关性。方法将入选冠心病患者180例根据ACC/AHA诊断指南分为稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组,又根据冠状动脉造影(CAG)结果分为1支病变组、2支病变组、3支病变组。以62例CAG正常者作为对照组。比较冠心病组和对照组一般临床资料以及血清D-D、PCT、Vit D水平的差异,并比较这3个指标在各组之间的差异。结果冠心病组血清D-D、PCT水平皆高于对照组,血清Vit D水平低于对照组(P<0.05)。在稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组中,D-D、PCT水平依次增高,Vit D水平依次降低(P<0.05)。随着冠状动脉病变支数的增多,D-D、PCT水平增高,Vit D水平降低。随着Gensini评分的增高,D-D、PCT水平增高,而Vit D水平降低。结论冠心病患者血清D-D、PCT水平随着病变程度加重而升高,而血清Vit D水平则相反。

Aim To explore the correlation between D-dimer( D-D),procalcitonin( PCT),vitamin D( Vit D)and coronary artery disease( CAD). Methods 180 patients with CAD were divided into stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group according to ACC/AHA diagnostic guidelines. The patients were also divided into single vessel lesion group,double vessel lesion group and three vessel lesion group according to the results of coronary angiography( CAG). 62 patients with normal CAG were used as control group. The differences of general clinical data and serum D-D,PCT,Vit D levels were compared between CAD group and control group,and the differences of these three indexes were compared among each group. Results The levels of serum D-D and PCT in CAD group were higher than those in control group,while the serum Vit D level was lower than that in control group( P<0.05). In stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group,D-D and PCT levels increased in turn,while Vit D level decreased in turn( P<0.05). With the increase of the number of coronary artery lesions,the levels of D-D and PCT increased,and the level of Vit D decreased. With the increase of Gensini score,D-D and PCT levels increased,while Vit D level decreased. Conclusion The levels of serum D-D and PCT in patients with CAD increase with the severity of lesions,while serum Vit D level is opposite.