革兰阴性菌外膜囊泡的研究进展

Research development of outer membrane vesicles in Gram-negative bacteria

外膜囊泡是由革兰阴性菌分泌产生,包含了多种生物分子,发挥重要生物功能,对于细菌的生存、定植、致病和细菌间及细菌与宿主间的细胞交流均有重大意义。本综述多方面地展示了外膜囊泡的合成与成分、作用与致病机制、提取方法和应用等各方面的研究进展。重点描述了其生物学功能。

Outer membrane vesicles (OMVs)were autonomically produced by Gram-negative bacteria,which contained a variety of biological molecules and played an important role in many biological functions such as the survival,colonization,pathopoiesis and cell-cell communications of the bacteria.This review shows us many aspects about OMVs,including the research progress of biogenesis and composition,function and pathogenic mechanism,and extraction methods.This review mainly focuses on its biological functions.